BICYCLIC COMPOUNDS AS .ALPHA.4.BETA.2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The present invention relates to novel bicyclic compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a...

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Hauptverfasser:	MOHAMMED, ABDUL RASHEED, JAYARAJAN, PRADEEP, RAVELLA, SRINIVASA RAO, KAMBHAMPTI, RAMA SASTRI, JASTI, VENKATESWARLU, NIROGI, RAMAKRISHNA, AHMAD, ISHTIYAQUE, SHINDE, ANIL KARBHARI, BHYRAPUNENI, GOPINADH, VEERAMALLA, SRINIVAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel bicyclic compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. These compounds are useful in the treatment and prevention of various disorders that are related to a4ß2 nicotinic receptors. La présente invention porte sur de nouveaux composés bicycliques de la formule (I), et sur leurs dérivés, promédicaments, tautomères, stéréoisomères, formes polymorphes, solvates, hydrates, métabolites, N-oxydes, sels pharmaceutiquement acceptables et compositions les contenants. La présente invention porte également sur un procédé de préparation des nouveaux composés précités, et sur leurs dérivés, promédicaments, tautomères, stéréoisomères, formes polymorphes, solvates, hydrates, métabolites, N-oxydes, sels pharmaceutiquement acceptables et compositions qui les contiennent. Ces composés sont utiles dans le traitement et la prévention de divers troubles qui sont en rapport avec les récepteurs a4ß2 nicotiniques.