METHODS FOR INCREASING DIVERSITY IN A LIBRARY OF POLYPEPTIDE LIGANDS
The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds w...
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| creator | LOAKES, DAVID TEUFEL, DANIEL PAUL HEINIS, CHRISTIAN BERNARD, ELISE WINTER, PAUL GREGORY |
| description | The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).
L'invention concerne un procédé pour modifier la diversité conformationnelle d'un premier répertoire de ligands polypeptidiques, comprenant une pluralité de polypeptides comprenant au moins deux groupes réactifs séparés par une séquence de boucle liée de manière covalente à un échafaudage moléculaire qui forme des liaisons covalentes avec lesdits groupes réactifs, pour produire un deuxième répertoire de ligands polypeptidiques, comprenant l'assemblage dudit deuxième répertoire des polypeptides et de l'échafaudage structural dudit premier répertoire, en incorporant l'une des modifications suivantes : (a) la modification d'au moins un groupe réactif; ou (b) la modification de la nature de l'échafaudage moléculaire; ou (c) la modification de la liaison entre au moins un groupe réactif et l'échafaudage moléculaire; ou (d) une combinaison quelconque de (a), (b) ou (c). |
| format | Patent |
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L'invention concerne un procédé pour modifier la diversité conformationnelle d'un premier répertoire de ligands polypeptidiques, comprenant une pluralité de polypeptides comprenant au moins deux groupes réactifs séparés par une séquence de boucle liée de manière covalente à un échafaudage moléculaire qui forme des liaisons covalentes avec lesdits groupes réactifs, pour produire un deuxième répertoire de ligands polypeptidiques, comprenant l'assemblage dudit deuxième répertoire des polypeptides et de l'échafaudage structural dudit premier répertoire, en incorporant l'une des modifications suivantes : (a) la modification d'au moins un groupe réactif; ou (b) la modification de la nature de l'échafaudage moléculaire; ou (c) la modification de la liaison entre au moins un groupe réactif et l'échafaudage moléculaire; ou (d) une combinaison quelconque de (a), (b) ou (c).</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180116&DB=EPODOC&CC=CA&NR=2770240C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180116&DB=EPODOC&CC=CA&NR=2770240C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOAKES, DAVID</creatorcontrib><creatorcontrib>TEUFEL, DANIEL PAUL</creatorcontrib><creatorcontrib>HEINIS, CHRISTIAN</creatorcontrib><creatorcontrib>BERNARD, ELISE</creatorcontrib><creatorcontrib>WINTER, PAUL GREGORY</creatorcontrib><title>METHODS FOR INCREASING DIVERSITY IN A LIBRARY OF POLYPEPTIDE LIGANDS</title><description>The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).
L'invention concerne un procédé pour modifier la diversité conformationnelle d'un premier répertoire de ligands polypeptidiques, comprenant une pluralité de polypeptides comprenant au moins deux groupes réactifs séparés par une séquence de boucle liée de manière covalente à un échafaudage moléculaire qui forme des liaisons covalentes avec lesdits groupes réactifs, pour produire un deuxième répertoire de ligands polypeptidiques, comprenant l'assemblage dudit deuxième répertoire des polypeptides et de l'échafaudage structural dudit premier répertoire, en incorporant l'une des modifications suivantes : (a) la modification d'au moins un groupe réactif; ou (b) la modification de la nature de l'échafaudage moléculaire; ou (c) la modification de la liaison entre au moins un groupe réactif et l'échafaudage moléculaire; ou (d) une combinaison quelconque de (a), (b) ou (c).</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDxdQ3x8HcJVnDzD1Lw9HMOcnUM9vRzV3DxDHMNCvYMiQQKKjgq-Hg6BTkGRSr4uykE-PtEBrgGhHi6uAKF3R39XIJ5GFjTEnOKU3mhNDeDvJtriLOHbmpBfnxqcUFicmpeakm8s6ORubmBkYmBszFhFQCsOSrR</recordid><startdate>20180116</startdate><enddate>20180116</enddate><creator>LOAKES, DAVID</creator><creator>TEUFEL, DANIEL PAUL</creator><creator>HEINIS, CHRISTIAN</creator><creator>BERNARD, ELISE</creator><creator>WINTER, PAUL GREGORY</creator><scope>EVB</scope></search><sort><creationdate>20180116</creationdate><title>METHODS FOR INCREASING DIVERSITY IN A LIBRARY OF POLYPEPTIDE LIGANDS</title><author>LOAKES, DAVID ; TEUFEL, DANIEL PAUL ; HEINIS, CHRISTIAN ; BERNARD, ELISE ; WINTER, PAUL GREGORY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2770240C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LOAKES, DAVID</creatorcontrib><creatorcontrib>TEUFEL, DANIEL PAUL</creatorcontrib><creatorcontrib>HEINIS, CHRISTIAN</creatorcontrib><creatorcontrib>BERNARD, ELISE</creatorcontrib><creatorcontrib>WINTER, PAUL GREGORY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LOAKES, DAVID</au><au>TEUFEL, DANIEL PAUL</au><au>HEINIS, CHRISTIAN</au><au>BERNARD, ELISE</au><au>WINTER, PAUL GREGORY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR INCREASING DIVERSITY IN A LIBRARY OF POLYPEPTIDE LIGANDS</title><date>2018-01-16</date><risdate>2018</risdate><abstract>The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).
L'invention concerne un procédé pour modifier la diversité conformationnelle d'un premier répertoire de ligands polypeptidiques, comprenant une pluralité de polypeptides comprenant au moins deux groupes réactifs séparés par une séquence de boucle liée de manière covalente à un échafaudage moléculaire qui forme des liaisons covalentes avec lesdits groupes réactifs, pour produire un deuxième répertoire de ligands polypeptidiques, comprenant l'assemblage dudit deuxième répertoire des polypeptides et de l'échafaudage structural dudit premier répertoire, en incorporant l'une des modifications suivantes : (a) la modification d'au moins un groupe réactif; ou (b) la modification de la nature de l'échafaudage moléculaire; ou (c) la modification de la liaison entre au moins un groupe réactif et l'échafaudage moléculaire; ou (d) une combinaison quelconque de (a), (b) ou (c).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | METHODS FOR INCREASING DIVERSITY IN A LIBRARY OF POLYPEPTIDE LIGANDS |
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