THIADIAZOLE-BASED COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER AND DIABETES

According to the invention there is provided a compound of formula (l) (see formula I) wherein: A represents C(=N-W-D) or S; B represents S or C(-NH-W-D); when: A represents C(=N-W-D) and B represents S then the bond between B and the NH atom is a single bond; or A represents S and B represents C(-NH-W-D) then the bond between B and the NH atom is a double bond; X represents -Q-[CR x R y]n-; W represents -[CR x R y]m- or -C(O)-[CR x R y]p-; Q represents a bond, -N(R a)-, -S-, or -O-; A1 to A5 respectively represent C(R1), C(R2), C(R3), C(R4) and C(R5), or, alternatively, up to two of A1 to A5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R6 groups, which compounds are useful in the treatment of cancer. La présente invention concerne un composé de formule (I). La signification des éléments X, W, A1 à A5 et D de la formule est donnée dans la description. Les composés de l'invention sont utiles dans le traitement des cancers.