NOVEL THIOPHENECARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

NOVEL THIOPHENECARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Disclosed is a compound having an effect of activating glucokinase. A medicinal composition which comprises, as the active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt of the same. In general formula (I), X represents a nitrogen atom or CR6 wherein...

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Hauptverfasser: WOLF, KAARINA KRISTINA, HIRAMATSU, NAOKI, LANG, MARTIN, KATAOKA, DAISUKE, GOTO, IZUMI, FUJIEDA, HIROKI, KATAOKA, HIROYO, IZUCHI, TOHRU, MIYAZAWA, TOSHIYUKI, HARADA, SATOKO, MIYOSHI, MIKA, SAKAIRI, MASAO, CHIKAMATSU, KAORI, WATANABE, NOBUHIDE, MURAKAMI, SEI, KATO, NORIYASU, SEIFERT, HANS-JUERGEN MARKUS, NAGAI, KAZUSHIGE, KASUGAI, NOBUYOSHI, YAMADA, YURIE, SUZUKI, KIMIE, YAMASHITA, TOKUYUKI, TAKAHASHI, NAOKI, KOGAMI, MASAKAZU, MAKINO, MITSUHIRO, TSURUTA, NOBUAKI, IWAI, HISAKAZU
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed is a compound having an effect of activating glucokinase. A medicinal composition which comprises, as the active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt of the same. In general formula (I), X represents a nitrogen atom or CR6 wherein R6 represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkylthio group; R2 represents a hydrogen atom or a fluorine atom; R3 represents a hydrogen atom or a C1-6 alkyl group; and one of R4 and R5 represents a hydrogen atom or a C1-6 alkyl group while the other represents a C1-6 alkylene carboxylic acid, a C1-6 alkylsulofonyl group, a C1-6 alkylcarbonyl group or CONH2.