ISOINDOLIN-1-ONE DERIVATIVES

ISOINDOLIN-1-ONE DERIVATIVES

A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GOLDING, BERNARD THOMAS, GRIFFIN, ROGER JOHN, RIEDINGER, CHRISTIANE, VALEUR, ERIC, WATSON, ANNA FRANCES, HARDCASTLE, IAN ROBERT, NOBLE, MARTIN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53. L'invention concerne des composés représentés par la formule (I): ou des composés représentés par la formule (II) ou bien des sels de qualité pharmaceutique de ces composés, ainsi que leur utilisation thérapeutique, en particulier pour le traitement du cancer ou comme inhibiteur de l'interaction entre la protéine et MDM2 et p53.