A SYSTEM AND METHOD FOR UNIAXIAL COMPRESSION OF AN ARTICLE, SUCH AS A THREE-DIMENSIONALLY PRINTED DOSAGE FORM

A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at t...

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Bibliographische Detailangaben
Hauptverfasser:	ROWE, CHARLES WILLIAM, CIMA, MICHAEL J, PRYCE LEWIS, WENDY E, MATERNA, PETER A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING BABY COMFORTERS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR RECEIVING SPITTLE DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form. Une forme posologique comprimée axialement fabriquée par impression tridimensionnelle préserve l'architecture interne prédéterminée de la forme posologique tout en produisant un fini de surface amélioré. La compression comprime la forme posologique et élimine au moins certains espaces vides qui restent à la fin de l'impression tridimensionnelle habituelle. Le fini de surface obtenu par le procédé de compression uniaxiale peut être essentiellement égal à celui obtenu de la compaction habituelle de comprimé. De plus, la structure interne ou la variation spatiale de la composition de la forme posologique est conservée pendant l'opération de compaction, où la compaction géométrique survient principalement dans la direction de l'axe de compaction. De plus, en conséquence de la compression, une plus grande quantité d'API peut être intégrée dans un volume final donné d'une forme posologique.