USE OF DEFIBRINATED BLOOD FOR MANUFACTURE OF A HEMOGLOBIN-BASED OXYGEN CARRIER

Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to form a suspension of red blood cells, thereby purifying the red blood cells. Whole blood is defibrinate...

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Bibliographische Detailangaben
Hauptverfasser:	HOUTCHENS, ROBERT A, LIGHT, WILLIAM R, GAWRYL, MARIA S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to form a suspension of red blood cells, thereby purifying the red blood cells. Whole blood is defibrinated by, for example, using a chemical coagulating agent or mechanical agitation. Separation of the plasma component from red blood cells can be completed by, for example, diafiltration. The suspension of red blood cells can then be employed to produce a hemoglobin-based oxygen carrier. Des globules rouges sont purifiés par défibrination de sang entier suivie dune filtration du sang entier défibriné, ce qui permet de séparer au moins une partie du constituant plasmatique des globules rouges, de former une suspension de globules rouges et de purifier les globules rouges. Le sang entier est défibriné, par exemple, au moyen dun agent de coagulation chimique ou par agitation mécanique. La séparation du constituant plasmatique des globules rouges peut être complétée, par exemple, par diafiltration. La suspension de globules rouges peut ensuite servir à produire un transporteur doxygène à base dhémoglobine.