USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES

The present invention relates to the field of medicine, in particular the use of an APL-type peptide, derived from the human 60 kDa heat-shock protein or analogues thereof, for preparing a pharmaceutical composition for treating Crohn's disease, ulcerative colitis and type 1 diabetes mellitus....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LORENZO PEREZ, NORAILYS, DOMINGUEZ HORTA, MARIA DEL CARMEN, PADRON PALOMARES, GABRIEL RAMON, FALCON CAMA, VIVIANA, MENENDEZ VALDES, IVON, BARBERA BETANCOURT, ARIANA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the field of medicine, in particular the use of an APL-type peptide, derived from the human 60 kDa heat-shock protein or analogues thereof, for preparing a pharmaceutical composition for treating Crohn's disease, ulcerative colitis and type 1 diabetes mellitus. Said peptide is biodistributed to the gastrointestinal tract and promotes the induction of apoptosis of activated T-cells of the intestinal lamina propria and of the peripheral blood of patients with Crohn's disease. Furthermore this peptide induces apoptosis of mononuclear cells of patients with type 1 diabetes mellitus.