HEMIFUMARATE SALT OF 1-[4-[1-(4-CYCLOHEXYL-3-TRIFLUOROMETHYL-BENZYLOXYIMINO)-ETHYL]-2-ETHYL-BENZYL]-A ZETIDINE-3-CARBOXYLIC ACID

This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. I...

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Bibliographische Detailangaben
Hauptverfasser:	CISZEWSKI, LECH, KARPINSKI, PIOTR H, DE LA CRUZ, MARILYN, MUTZ, MICHAEL, RIEGERT, CHRISTIAN, SCHNEEBERGER, RICARDO, VOGEL, CASPAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment. Cette invention porte sur un sel hémifumarate d'acide 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxyimino]-éthyl}-2-éthyl-benzyl)-azétidine-3-carboxylique (Composé I), sur des compositions pharmaceutiques comprenant ce sel, sur des procédés de formation de ce sel et sur son utilisation dans un traitement médical. De plus, la présente invention porte également sur de nouvelles formes polymorphes de la forme sel hémifumarate du Composé I, ainsi que sur des compositions pharmaceutiques comprenant ces formes polymorphes, sur des procédés permettant de les obtenir et sur leur utilisation dans un traitement médical.