COMPOUND HAVING TAFIA INHIBITORY ACTIVITY

A compound having excellent TAFIa inhibitory activity. Specifically disclosed is a compound represented by formula (I) or a salt thereof. In the formula, A represents a benzene ring or a pyridine ring; X represents -(CH2)-, -(CH2)2-, an oxygen atom, a nitrogen atom or a single bond; Y represents -(...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUDA, DAISUKE, BOHNO, MASAHIRO, AMADA, HIDEAKI, BOHNO, AYAKO, SAITO, SHIUJI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A compound having excellent TAFIa inhibitory activity. Specifically disclosed is a compound represented by formula (I) or a salt thereof. In the formula, A represents a benzene ring or a pyridine ring; X represents -(CH2)-, -(CH2)2-, an oxygen atom, a nitrogen atom or a single bond; Y represents -(CH2)3-NH-R3, -(CH2)4-NH-R3 or a 2-aminopyridyl group; R3 represents a hydrogen atom or the like; R1 represents a hydrogen atom or the like; R2 represents CO2R8, a tetrazolyl group or the like; R8 represents a hydrogen atom, a C1-10 alkyl group or a group having a structure of formula (Ib) or (Ic); and m and n each represents an integer of 0 or 1.