METHODS FOR PRESERVING AND/OR INCREASING RENAL FUNCTION USING XANTHINE OXIDOREDUCTASE INHIBITORS

The present invention relates to the use of xanthinoxidoreductase inhibitors, or a pharmaceutically acceptable salt thereof, for improving of renal function in a subject in need thereof, such that the renal function of the subject is preserved and the subject does not exhibit further age expected decline in renal function. The xanthinoxidoreductase inhibitors of the present invention are exemplified by compounds that comprise the formula: wherein R1 and R2 are each independently a hydrogen, a hydroxyl group, a COOH group, an unsubstituted or substituted C1-C10 alkyl group, an unsubstituted or substituted C1-C10 alkoxy, an unsubstituted or substituted hydroxyalkoxy, a phenylsulfinyl group or a cyano (-CN) group, and wherein R3 and R4 are each independently a hydrogen or have the structure of Formula A and T connects A to the aromatic ring shown above at R1, R2, R3 or R4: and wherein R5 and R6 are each independently a hydrogen, a hydroxyl group, a COOH group, an unsubstituted or substituted C1-C10 alkyl group, an unsubstituted or substituted C1-C10 alkoxy, an unsubstituted or substituted hydroxyalkoxy, COO-Glucoronide or COO-Sulfate.