COMBINATION THERAPY FOR TUBERCULOSIS

The present invention relates to methods of treating tuberculosis, including multi~ drug resistant varieties and la-tent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising ad-ministering to said mammal in need thereof an effecti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BRICKNER, STEVEN JOSEPH, NUERMBERGER, ERIC, STOVER, CHARLES KENDALL
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present invention relates to methods of treating tuberculosis, including multi~ drug resistant varieties and la-tent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising ad-ministering to said mammal in need thereof an effective amount of a compound of formula (I), (S)-N- [[3-[3-fluoro-4-(4-thiomor-pholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. The present invention also relates to a pharmaceutical composition com-prising a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, (ii) a therapeutically effective amount of at least one agent useful in the treatment of tuberculosis and (iii) one or more pharmaceu-tically acceptable carriers or vehicles.