PROCESS FOR THE MANUFACTURE OF AN INTERMEDIATE PRODUCT OF DABIGATRAN ETEXILATE

PROCESS FOR THE MANUFACTURE OF AN INTERMEDIATE PRODUCT OF DABIGATRAN ETEXILATE

The invention relates to a method for producing the compound of formula 1: (see formula 1) comprising reacting a diamine of formula 2 (see formula 2) with an oxadiazolone of formula 3 (see formula 3) to form a compound of formula 4 (see formula 4) and converting the compound of formula 4 without iso...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DERSCH, WOLFGANG, HAMM, RAINER, KOCH, GUNTER, SCHOLZ, ULRICH, ZERBAN, GEORG, FILSER, CHRISTIAN, HAUSHERR, ARNDT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a method for producing the compound of formula 1: (see formula 1) comprising reacting a diamine of formula 2 (see formula 2) with an oxadiazolone of formula 3 (see formula 3) to form a compound of formula 4 (see formula 4) and converting the compound of formula 4 without isolation, into the amidine of formula 1 by hydrogenation and addition of p-toluenesulphonic acid and ammonia. L'invention concerne un procédé pour produire le composé de la formule 1 caractérisé en ce qu'on fait réagir une diamine de la formule 2 avec une oxadiazolone de la formule 3 pour obtenir un composé de la formule 4 qui est converti sans isolation par hydrogénation et ajout d'acide p- toluolsulfonique et d'ammoniac en amidine de la formule 1.