SYNTHESIS OF ACYCLIC NUCLEOSIDE DERIVATIVES

SYNTHESIS OF ACYCLIC NUCLEOSIDE DERIVATIVES

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acce...

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Hauptverfasser: TIAN, ZHENPING, WAYNE, GREG, ZHANG, WEIJIANG, RILEY, DAVID A, LEANNA, M. ROBERT, PATEL, RAMESH R, LANNOYE, GREG, LUKIN, KIRILL L, TIEN, JIEN-HEH J, CHANG, SOU-JEN, RASMUSSEN, MICHAEL, KOLACZKOWSKI, LAWRENCE, NARAYANAN, BIKSHANDARKOR A, HANNICK, STEVEN M, SINGAM, PULLA REDDY, BHAGAVATULA, LAKSHMI, MORTON, HOWARD, GATES, BRADLEY D
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.