SYNTHESIS OF IODIXANOL IN WATER

This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'- bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- isophthalamide with water...

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Hauptverfasser: BREKKE, GEIR, SVENDSEN, TERJE, ROGNE, OTTO, KJERNLI, TROND
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creator BREKKE, GEIR
SVENDSEN, TERJE
ROGNE, OTTO
KJERNLI, TROND
description This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'- bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- isophthalamide with water as solvent. La présente invention concerne la synthèse diodixanol(1,3-bis(acétamido)-N,N- bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophényl]-2-hydroxypropane), plus particulièrement la dimérisation du 5-acétamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophtalamide avec leau comme solvant.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title SYNTHESIS OF IODIXANOL IN WATER
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