PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SODIUM-DEPENDENT GLUCOSE TRANSPORTER (SGLT)

The present invention includes a process for the preparation of compounds of formula (I) having inhibitory activity against sodium-dependent glucose transporter (SGLT). The process includes a one-step coupling of a compound of formula (V) with a compound of formula (VI-S) in the presence of an alkyl...

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Bibliographische Detailangaben
Hauptverfasser:	MEHRMAN, STEVEN, WELLS, KENNETH M, ABDEL-MAGID, AHMED F, NOMURA, SUMIHIRO, SCOTT, LORRAINE, CHISHOLM, MAUREEN, KOGA, YUICHI, ZHANG-PLASKET, FAN, HONGU, MITSUYA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention includes a process for the preparation of compounds of formula (I) having inhibitory activity against sodium-dependent glucose transporter (SGLT). The process includes a one-step coupling of a compound of formula (V) with a compound of formula (VI-S) in the presence of an alkyl lithium, which may be selected from (trimethylsilyl)methyl lithium, 2,4,6-trimethylphenyl lithium and (triethylsilyl)methyl lithium. (see formula I) (see formula V) (see formula VI-S) La présente invention porte sur un nouveau procédé pour la préparation de composés ayant une activité inhibitrice contre un transporteur du glucose dépendant du sodium (SGLT) présent dans l'intestin ou le rein.