STABILIZED DOXERCALCIFEROL AND PROCESS FOR MANUFACTURING THE SAME

STABILIZED DOXERCALCIFEROL AND PROCESS FOR MANUFACTURING THE SAME

1.alpha.-hydroxyvitamin D2 (doxercalciferol) of exceptionally high purity and stability is prepared by a process involving chromatographically purifying 1.alpha.- hydroxyvitamin D2 monoacetate, chemically removing the acetate protectant group from the purified product to form 1.alpha.-hydroxyvitamin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GORIN, BORIS IVANOVICH, MCGOWAN, GRAHAM
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:1.alpha.-hydroxyvitamin D2 (doxercalciferol) of exceptionally high purity and stability is prepared by a process involving chromatographically purifying 1.alpha.- hydroxyvitamin D2 monoacetate, chemically removing the acetate protectant group from the purified product to form 1.alpha.-hydroxyvitamin D2, and precipitating the 1.alpha.- hydroxyvitamin D2 so formed from a mixed organic solvent consisting essentially of at least one C1 - C6 dialkyl ether or C1 - C6 alkyl ester, and at least one C5 - C12 hydrocarbon.