A METHOD FOR IMPROVEMENT OF DIFFERENTIATION OF MESENCHYMAL STEM CELLS USING A DOUBLE-STRUCTURED TISSUE IMPLANT

A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, ROBERT LANE, SHORTKROFF, SONYA, CLAESSON, HANS P. I, TARRANT, LAURENCE J. B, KHOURY, JOSEPH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. La présente invention concerne un implant tissulaire à double structure (DSTI) et un procédé destiné de préparation et d'utilisation de celui-ci permettant son implantation dans des lésions tissulaires. L'implant tissulaire à double structure est destiné à la différenciation, la croissance et la transformation de cellules, de cellules souches, de cellules souches mésenchymateuses et de cellules souches de la moelle osseuse. Le DSTI comprend un support principal et un support secondaire comprenant une solution de collagène soluble combinée à un agent de surface non ionique généré et positionné dans le support principal.