5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

The present invention relates to compounds of formula (I) or pharmaceutic al acceptable salts, wherein A, R1, R2, R3 and m, are defined in the descrip tion. The present invention relates also to methods of making said compounds , and compositions containing said compounds which are useful for inhibi...

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Hauptverfasser: TEUSCH, NICOLE, AKRITOPOULOU-ZANZE, IRINI, SHUAI, QI, MACK, HELMUT, DJURIC, STEVAN W, GASIECKI, ALAN F, SARRIS, KATHY, KOVAR, PETER J, HOBSON, ADRIAN, TURNER, SEAN C, WANG, LU, BAKKER, MARGARETHA, VASUDEVAN, ANIL, FRANK, KRISTINE, JOHNSON, ERIC T, ST. JOHN MOORE, NIGEL, LONG, ANDREW J, MICHMERHUIZEN, MELISSA J, GRACIAS, VIJAYA J, PATEL, JYOTI R, WAKEFIELD, BRIAN D, LI, BIQIN, GEORGE, DAWN, KALVIN, DOUGLAS M
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula (I) or pharmaceutic al acceptable salts, wherein A, R1, R2, R3 and m, are defined in the descrip tion. The present invention relates also to methods of making said compounds , and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janu s Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.