SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES

This invention provides a class of compounds which are useful for specifi cally inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-depend ent kinases, including cancer, viral infections (e.g., HIV) neurodegenera...

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Bibliographische Detailangaben
Hauptverfasser:	ALI, SIMAK, COOMBES, RCDS, BARRETT, ANTHONY G. M, LIOTTA, DENNIS C, SNYDER, JAMES P, JOGALEKAR, ASHUTOSH S, SIWICKA, ALEKSANDRA, SCHEIPER, BODO, BRACKOW, JAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	This invention provides a class of compounds which are useful for specifi cally inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-depend ent kinases, including cancer, viral infections (e.g., HIV) neurodegenerativ e disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. a therosclerosis). Moreover, certain members of this class are particularly us eful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.