POLYFUNCTIONAL FULLERENE C60 AMINO ACID DERIVATIVES

The invention relates to novel polyfunctional fullerene C60 aminoacid der ivatives of formula (1), wherein R=H, mono- or dihydroxyalkyl, aminoalkyl, h aloidalkyl, mono- or dinitroxyalkyl or maleinimide mm; N-Z are the .alpha.,. beta.,.gamma., .omega.-aminoacid of general formula NH-CmH2 m-COOM or (I...

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Hauptverfasser:	KOTELNIKOVA, RAISA ALEKSEEVNA, DAVYDOV, MIKHAIL IVANOVICH, ALDOSHIN, SERGEI MIKHAILOVICH, BOGDANOV, GENNADY NIKOLAEVICH, ROMANOVA, VALENTINA SEMENOVNA, FROG, ELENA SERGEEVNA, BUBNOV, YURY NIKOLAEVICH, KONOVALOVA, NINA PETROVNA, FAINGOLD, IRINA IGOREVNA, PISARENKO, OLEG IVANOVICH, KOTELNIKOV, ALEXANDR IVANOVICH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to novel polyfunctional fullerene C60 aminoacid der ivatives of formula (1), wherein R=H, mono- or dihydroxyalkyl, aminoalkyl, h aloidalkyl, mono- or dinitroxyalkyl or maleinimide mm; N-Z are the .alpha.,. beta.,.gamma., .omega.-aminoacid of general formula NH-CmH2 m-COOM or (II) - N- COOM, wherein m=2-5 and M is a nitroxyalkyl group, an alkyl group or an a lkali metal salt, or a biologically active dipeptide, to methods for the pro duction thereof and to a method for binding fullerene derivatives with SH-co ntaining proteins. The invention also relates to the use of nitroxyalkyl-(fu llerenyl)aminoacids as nitrogen monoxide donors and to the use of said nitro xyalkyl-(fullerenyl)aminoacids in the form of quick-acting vasodilatators fo r antihypertensive therapy. A method for inhibiting a metastasis process and a method for enhancing antileukemik activity of cyclophosphamide are also d isclosed.