AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS

The present invention is directed to compounds, compositions and methods for treating or preventing viral infec-tions, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3'-azido-2',3'-dideoxy purine nucleosides or phosphonates, and pharmaceut...

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Bibliographische Detailangaben
Hauptverfasser:	SHI, JUNXING, SCHINAZI, RAYMOND F, MELLORS, JOHN W, COATS, STEVEN J, AMBLARD, FRANK, WHITAKER, RICHARD ANTHONY, SLUIS-CREMER, NICOLAS PAUL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention is directed to compounds, compositions and methods for treating or preventing viral infec-tions, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3'-azido-2',3'-dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrug s, and other derivatives thereof. In particular, the com-pounds show potent antiviral activity against HIV-1 resistance mutants including HIV-1K65R, HTV-1K70E, HIV-1L74V, HIV-1M184V, HIV-1Q151M and inhibitory activity against HIV-1 RT harboring TAMS or insertion mutations including HIV-1AZT3, HIV-1AZT7, HIV-1AZT9, HIV- 1Q151M, or HIV-1 69insertion. In one embodiment, the compoun ds are 3'-azido-ddA, 3'-azido-ddG, or combinations thereof, administered with one or more additional antiviral agents that sele ct for TAM mutations and/or the M 184V mutation, along with a pharmaceutically acceptable carrier.