COMPOUNDS AND METHODS FOR ENHANCING SOLUBILITY OF FLORFENICOL AND STRUCTURALLY-RELATED ANTIBIOTICS USING CYCLODEXTRINS

COMPOUNDS AND METHODS FOR ENHANCING SOLUBILITY OF FLORFENICOL AND STRUCTURALLY-RELATED ANTIBIOTICS USING CYCLODEXTRINS

The relatively low solubility of florfenicol (FFC) in water (1.3mg/mL) li mits its use in medicated drinking water systems for treatment of pulmonary disease of swine and poultry. Current formulations use a high volume organic solvent to reach the required FFC concentration of 13.5mg/mL in an automa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TONGIANI, SERENA, FREEHAUF, KEITH ALAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The relatively low solubility of florfenicol (FFC) in water (1.3mg/mL) li mits its use in medicated drinking water systems for treatment of pulmonary disease of swine and poultry. Current formulations use a high volume organic solvent to reach the required FFC concentration of 13.5mg/mL in an automate d proportioner mixing tank system, with practical disadvantages for the user s in the field. This invention relates to the effects of complex formation w ith natural and modified cyclodextrins on the aqueous solubility of FFC and antibiotics of related structure. Furthermore, this invention relates to the effects of polyethylene glycol (PEG-300) as a co-solvent in an FFC-cyclodex trin system to achieve the required FFC dose in the mixing tank system and t o avoid high volumes of the organic solvent.