SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS

The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocyclyl fused gamma-carbolines. The process of the present invention is a more efficient pro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	YAO, WEI, CHENG, HUA, ZHANG, QIANG, BEARD, JAMES DAVID, TOMESCH, JOHN CHARLES, THOMPSON, ANDREW S, LI, PENG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocyclyl fused gamma-carbolines. The process of the present invention is a more efficient process for preparing enantiomerically pure substituted heterocycle fused gamma-carbolines. The compounds of the present invention are useful as 5-HT2 receptor agonists and antagonists used in treating disorders of the central nervous system. L'invention concerne des procédés pour la préparation de gamma-carbolines fusionnées à hétérocycles substitués, des intermédiaires utiles pour leur production, et des procédés pour produire de tels intermédiaires et de tels gamma-carbolines fusionnés à hétérocycles.