PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS

The present invention is directed to compounds of the structural Formula: wherein: R1 is H or -C1-C3 alkyl; R2 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is sele cted from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -C...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MICHAEL, LAURA FREY, MA, TIANWEI, MOKUBE, FESE MAMBO, PFEIFER, LANCE ALLEN, MONTROSE-RAFIZADEH, CHAHRZAD, MANTLO, NATHAN BRYAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention is directed to compounds of the structural Formula: wherein: R1 is H or -C1-C3 alkyl; R2 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is sele cted from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2 -cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R1 and R2 are each H, then R3 is s elected from the group consisting of -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2- cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with f rom 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.