USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE

USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE

The present invention is directed to methods of enhancing insulin release , GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucag ons secretion, and methods of inhibiting food intake, and methods of trea...

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Bibliographische Detailangaben
Hauptverfasser: SALEMME, F. RAYMOND, LEE, S. PAUL, CERNE, ROK, BRYANT, ROBERT, MORGAN, GILLIAN, ZHOU, PEIHONG, BUBER, M. N. TULU
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention is directed to methods of enhancing insulin release , GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucag ons secretion, and methods of inhibiting food intake, and methods of treatin g diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibi tor.