KILLER IG-LIKE RECEPTOR (KIR) ANTIBODIES, FORMULATIONS, AND USES THEREOF

Inhibitory Killer lg-Like Receptors (KIRs) on NK cells inhibit the activation of NK cell cytotoxicity required to clear cancer cells and other diseased cells in a subject. An IgG4 isotype anti-KIR antibody (1-7F9) overcomes the KIR-mediated inhibition of NK cell activation and, thus, potentiates NK...

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Bibliographische Detailangaben
Hauptverfasser:	SVENSSON, ROZANA, OVERGAARD, RUNE VIIG, WAGTMANN, PETER ANDREAS NICOLAI REUMERT, SVENDSEN, IVAN, ALIFRANGIS, LENE HJORTH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Inhibitory Killer lg-Like Receptors (KIRs) on NK cells inhibit the activation of NK cell cytotoxicity required to clear cancer cells and other diseased cells in a subject. An IgG4 isotype anti-KIR antibody (1-7F9) overcomes the KIR-mediated inhibition of NK cell activation and, thus, potentiates NK cell-mediated cytotoxicity. The pharmacokinetics and pharmacodynamics of 1-7F9 is assessed in pre-clinical and clinical trials in order to determine a dosing frequency that is effective to potentiate NK cell cytotoxicity (i.e., modulate NK cells and/or treat cancer). L'invention porte sur un nouvel anticorps anti-KIR isotype IgG4, sur de nouvelles formulations de celui-ci et d'autres anticorps anti-KIR IgG4, et sur des procédés d'utilisation de telles formulations. L'invention porte également sur des compositions, des formulations, des dosages et des régimes d'administration appropriés pour une activation des lymphocytes NK et des applications thérapeutiques d'anticorps anti-KIR, ainsi que sur des coffrets comprenant un ou plusieurs anticorps anti-KIR avec des instructions pour une utilisation dans le traitement du cancer.