N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example. L'invention concerne...

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Bibliographische Detailangaben
Hauptverfasser:	MILLER, WILLIAM HENRY, ZIMMERMAN, MICHAEL N, SHAW, ANTONY N, DUFFY, KEVIN J, MYERS, ANDREA K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example. L'invention concerne certains dérivés de glycine N-substitués de type pyridazinedione de formule (I) qui sont des antagonistes de prolyl hydroxylases HIF et sont utiles pour le traitement de maladies bénéficiant de l'inhibition de cette enzyme, l'anémie étant un exemple.