PROCESS FOR PREPARING 3,5-DI-OMICRON-ACYL-2-FLUORO-2-C-METHYL-D-RIBONO-GAMMA-LACTONE

PROCESS FOR PREPARING 3,5-DI-OMICRON-ACYL-2-FLUORO-2-C-METHYL-D-RIBONO-GAMMA-LACTONE

The present invention provides a novel process for the preparation of 3,5-di-O- acyl-2-fluoro-2-C-methyl-D-ribono-g-lactone derivatives of formula (2) which are key intermediates in the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-.beta.-D-ribofuranosyl)cytosine (formula (1)) a compound that posses...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG, PINGSHENG, CEDILOTE, MIALL, CLEARY, THOMAS P, IDING, HANS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a novel process for the preparation of 3,5-di-O- acyl-2-fluoro-2-C-methyl-D-ribono-g-lactone derivatives of formula (2) which are key intermediates in the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-.beta.-D-ribofuranosyl)cytosine (formula (1)) a compound that possesses potent and selective anti-hepatitis C virus activity.