USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI

The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, charact erized in that it is capable of specifically binding to a bacterium belongin g to the group of mutans Streptococci, wherein the specific binding is (i...

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Bibliographische Detailangaben
Hauptverfasser:	LANG, CHRISTINE, BOTTNER, MEWES, REINDL, ANDREAS, VEEN, MARKUS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, charact erized in that it is capable of specifically binding to a bacterium belongin g to the group of mutans Streptococci, wherein the specific binding is (i) r esistant to heat treatment; and/or (ii) resistant to protease treatment; and /or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4. 5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries c aused by mutans Streptococci other than Streptococcus mutans. Preferably, th e specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belongi ng to the group of mutans Streptococci which has been grown to stationary ph ase; (c) incubating the mixture obtained in step (b) under conditions allowi ng the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophyl axis or treatment of caries caused by mutans Streptococci other than Strepto coccus mutans, comprising administering a microorganism belonging to the gro up of lactic acid bacteria characterized in that said microorganism is capab le of specifically binding to a bacterium belonging to the group of mutans S treptococci or a mutant, derivative, analog or fragment of said microorganis m.