OPTIMIZED NON-CANONICAL ZINC FINGER PROTEINS

Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are al...

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Bibliographische Detailangaben
Hauptverfasser:	GARRISON, ROBBI J, SHUKLA, VIPULA K, MITCHELL, JON C, URNOV, FYODOR, BLUE, RYAN C, WORDEN, SARAH E, PETOLINO, JOSEPH F, CAI, QIHUA C, BAKER, LISA W, MILLER, JEFFREY, ARNOLD, NICOLE L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described L'invention concerne des doigts de zinc comprenant des résidus de coordination de zinc CCHC. L'invention concerne également des protéines à doigts de zinc et des protéines hybrides comprenant ces doigts de zinc CCHC ainsi que des polynucléotides codant pour ces protéines. Elle se rapporte en outre à des méthodes d'utilisation de ces protéines pour l'édition de gènes et la régulation de gènes.