METHOD OF ISOLATING BIOMACROMOLECULES USING LOW PH AND DIVALENT CATIONS

The present invention is related to a method of isolating a biological macromolecule in a composition. Specifically, the present invention is directed to a method of isolating a biomacromolecule in a composition containing an impurity, the method comprising (a) lowering the pH of the composition, (b...

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Bibliographische Detailangaben
Hauptverfasser:	DE VILMORIN, PHILIPPE GEORGES, ROMERO, JONATHAN, CHROSTOWSKI, JAMES, CASE, JENNIFER YUN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention is related to a method of isolating a biological macromolecule in a composition. Specifically, the present invention is directed to a method of isolating a biomacromolecule in a composition containing an impurity, the method comprising (a) lowering the pH of the composition, (b) adding a divalent cation to the composition, and (c) separating the biomacromolecule from the impurity. La présente invention concerne un procédé d'isolement d'une macromolécule biologique dans une composition. Précisément, la présente invention concerne un procédé d'isolement d'une biomacromolécule dans une composition contenant une impureté, le procédé comportant (a) l'abaissement du pH de la composition, (b) l'ajout d'un cation divalent à la composition et (c) la séparation de la biomacromolécule de l'impureté.