A PROCESS FOR THE PREPARATION OF E-3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL] BENZALDEHYDE, A KEY INTERMEDIATE FOR SYNTHESIZING MONTELUKAST ACID AND ITS SALT

A PROCESS FOR THE PREPARATION OF E-3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL] BENZALDEHYDE, A KEY INTERMEDIATE FOR SYNTHESIZING MONTELUKAST ACID AND ITS SALT

This invention relates to a process for the preparation of 3-[2-(7-chloro- 2- quinolinyl)ethenyl]benzaldehyde (II) which comprises of; a) reacting 7-chloroquinaldine (III) with isopthaldehyde (IV) in the presenc e of a base, acid or a combination thereof in a single organic solvent b) isolating the...

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Bibliographische Detailangaben
Hauptverfasser: RAWAT, AJAY SINGH, KADU, RUSHIKESH, CHATTERJEE, SUGATA, CHAVDA, MUKESH, KUMAR, NEERAJ
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:This invention relates to a process for the preparation of 3-[2-(7-chloro- 2- quinolinyl)ethenyl]benzaldehyde (II) which comprises of; a) reacting 7-chloroquinaldine (III) with isopthaldehyde (IV) in the presenc e of a base, acid or a combination thereof in a single organic solvent b) isolating the crude intermediate by filtration from the reaction mixture c) purifying the wet crude to remove the bis adduct of formula (V) by crystallization from an organic solvent. (see formula II)