TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTSOF INTEGRIN .ALPHA.NU.BETA.6

The present invention relates to methods of asthma treatment and preventi on using .alpha.v.beta.6 antagonists, such as .alpha.v.beta.6-binding antibo dies. In particular, the invention relates to the discovery of a correlation between reduced expression of .alpha.v.beta.6and the protection from the...

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Hauptverfasser:	VIOLETTE, SHEILA M, HUANG, XIAOZHU, SHEPPARD, DEAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to methods of asthma treatment and preventi on using .alpha.v.beta.6 antagonists, such as .alpha.v.beta.6-binding antibo dies. In particular, the invention relates to the discovery of a correlation between reduced expression of .alpha.v.beta.6and the protection from the in crease in airway sensitivity seen in chronic allergen-challenged mice. This protection is associated with protection from the usual allergen-induced inc rease in airway epithelial mast cells.