PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION

PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION

The invention provides compounds according to formula (I) their use and m ethods for preparation wherein A, X, Y, R1, R2 and R3 are defined herein. Th e compounds of the invention inhibit specific serine/threonine kinases invol ved in inflammatory processes and aberrant cell proliferation, and are t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MORWICK, TINA MARIE, MAO, WANG, PROKOPOWICZ, ANTHONY S
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides compounds according to formula (I) their use and m ethods for preparation wherein A, X, Y, R1, R2 and R3 are defined herein. Th e compounds of the invention inhibit specific serine/threonine kinases invol ved in inflammatory processes and aberrant cell proliferation, and are thus useful for treating associated diseases and pathological conditions such as Pim kinase-mediated diseases and pathological conditions involving inflammat ion, including Chron's disease, inflammatory bowel disease, rheumatoid arthr itis, and chronic inflammatory disease, or aberrant cell proliferation inclu ding various cancers.