BIOFOULING SELF-COMPENSATING BIOSENSOR

An in vivo biosensor disposed upon a subject comprising an electrochemica l cell having a plurality of electrodes and a computer-controlled voltage so urce incorporating a potentiostat that is generative of a poise potential re gime, which computer-controlled voltage source is operationally coupled to a computing device that: computes an output current whose magnitude is propor tional to an amount of an analyte in a bodily fluid of the subject; and, adj usts the output current for drift due to biofouling at points in time greate r than or equal to an induction period; and, outputs the amount of the analy te by transducing the adjusted output current. Methods and algorithms for ad justing the output current for drift due to biofouling are provided.