NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY
[PROBLEMS] To provide a thyroid hormone receptor ligand having satisfacto ry levels of pharmacological effects and safety and also having excellent ph armaceutical activities. [MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof...
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| creator | ASANO, YUKIYASU MAEDA, KOJI MURASE, TORU TSURUTA, NOBUAKI |
| description | [PROBLEMS] To provide a thyroid hormone receptor ligand having satisfacto ry levels of pharmacological effects and safety and also having excellent ph armaceutical activities. [MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. [ Chemical formula 1] (I) wherein [Chemical formula 2] represents a single or double bond; A represents ~CH2- or ~CO-; X, Y and Z independently represent a nitrogen atom or a carbon atom; R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group, an aralkyl group or the like; R3 repres ents a hydrogen atom, an alkyl group or the like; R4 represents a hydrogen a tom or an alkyl group; R5 represents a hydrogen atom, an alkyl group, a halo lower alkyl group or the like; R6 represents a hydrogen atom or an alkyl gr oup; R7 represents a hydrogen atom or the like; R8 represents a hydrogen ato m, an alkyl group or the like; E represents ~NHCO-G-COR12 or the like; G rep resents a single bond or an alkylene group; and R12 represents a hydroxy gro up or an alkoxy group. |
| format | Patent |
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[MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. [ Chemical formula 1] (I) wherein [Chemical formula 2] represents a single or double bond; A represents ~CH2- or ~CO-; X, Y and Z independently represent a nitrogen atom or a carbon atom; R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group, an aralkyl group or the like; R3 repres ents a hydrogen atom, an alkyl group or the like; R4 represents a hydrogen a tom or an alkyl group; R5 represents a hydrogen atom, an alkyl group, a halo lower alkyl group or the like; R6 represents a hydrogen atom or an alkyl gr oup; R7 represents a hydrogen atom or the like; R8 represents a hydrogen ato m, an alkyl group or the like; E represents ~NHCO-G-COR12 or the like; G rep resents a single bond or an alkylene group; and R12 represents a hydroxy gro up or an alkoxy group.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080103&DB=EPODOC&CC=CA&NR=2655913A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080103&DB=EPODOC&CC=CA&NR=2655913A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ASANO, YUKIYASU</creatorcontrib><creatorcontrib>MAEDA, KOJI</creatorcontrib><creatorcontrib>MURASE, TORU</creatorcontrib><creatorcontrib>TSURUTA, NOBUAKI</creatorcontrib><title>NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY</title><description>[PROBLEMS] To provide a thyroid hormone receptor ligand having satisfacto ry levels of pharmacological effects and safety and also having excellent ph armaceutical activities. [MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. [ Chemical formula 1] (I) wherein [Chemical formula 2] represents a single or double bond; A represents ~CH2- or ~CO-; X, Y and Z independently represent a nitrogen atom or a carbon atom; R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group, an aralkyl group or the like; R3 repres ents a hydrogen atom, an alkyl group or the like; R4 represents a hydrogen a tom or an alkyl group; R5 represents a hydrogen atom, an alkyl group, a halo lower alkyl group or the like; R6 represents a hydrogen atom or an alkyl gr oup; R7 represents a hydrogen atom or the like; R8 represents a hydrogen ato m, an alkyl group or the like; E represents ~NHCO-G-COR12 or the like; G rep resents a single bond or an alkylene group; and R12 represents a hydroxy gro up or an alkoxy group.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDw8w9z9VEw0zVVcPJ0jnT2dFbwcA1xDfIHsn2AHBfXIM8wxxDPMFcFRz8XBc-QYIUAD8cgX0dn19AQT2dHHwUg5eMZEsnDwJqWmFOcyguluRkU3FxDnD10Uwvy41OLCxKTU_NSS-KdHY3MTE0tDY0dDY2JUAIAiUksMA</recordid><startdate>20080103</startdate><enddate>20080103</enddate><creator>ASANO, YUKIYASU</creator><creator>MAEDA, KOJI</creator><creator>MURASE, TORU</creator><creator>TSURUTA, NOBUAKI</creator><scope>EVB</scope></search><sort><creationdate>20080103</creationdate><title>NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY</title><author>ASANO, YUKIYASU ; MAEDA, KOJI ; MURASE, TORU ; TSURUTA, NOBUAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2655913A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ASANO, YUKIYASU</creatorcontrib><creatorcontrib>MAEDA, KOJI</creatorcontrib><creatorcontrib>MURASE, TORU</creatorcontrib><creatorcontrib>TSURUTA, NOBUAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ASANO, YUKIYASU</au><au>MAEDA, KOJI</au><au>MURASE, TORU</au><au>TSURUTA, NOBUAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY</title><date>2008-01-03</date><risdate>2008</risdate><abstract>[PROBLEMS] To provide a thyroid hormone receptor ligand having satisfacto ry levels of pharmacological effects and safety and also having excellent ph armaceutical activities. [MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. [ Chemical formula 1] (I) wherein [Chemical formula 2] represents a single or double bond; A represents ~CH2- or ~CO-; X, Y and Z independently represent a nitrogen atom or a carbon atom; R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group, an aralkyl group or the like; R3 repres ents a hydrogen atom, an alkyl group or the like; R4 represents a hydrogen a tom or an alkyl group; R5 represents a hydrogen atom, an alkyl group, a halo lower alkyl group or the like; R6 represents a hydrogen atom or an alkyl gr oup; R7 represents a hydrogen atom or the like; R8 represents a hydrogen ato m, an alkyl group or the like; E represents ~NHCO-G-COR12 or the like; G rep resents a single bond or an alkylene group; and R12 represents a hydroxy gro up or an alkoxy group.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY |
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