NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY

[PROBLEMS] To provide a thyroid hormone receptor ligand having satisfacto ry levels of pharmacological effects and safety and also having excellent ph armaceutical activities. [MEANS FOR SOLVING PROBLEMS] A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. [ Chemical formula 1] (I) wherein [Chemical formula 2] represents a single or double bond; A represents ~CH2- or ~CO-; X, Y and Z independently represent a nitrogen atom or a carbon atom; R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group, an aralkyl group or the like; R3 repres ents a hydrogen atom, an alkyl group or the like; R4 represents a hydrogen a tom or an alkyl group; R5 represents a hydrogen atom, an alkyl group, a halo lower alkyl group or the like; R6 represents a hydrogen atom or an alkyl gr oup; R7 represents a hydrogen atom or the like; R8 represents a hydrogen ato m, an alkyl group or the like; E represents ~NHCO-G-COR12 or the like; G rep resents a single bond or an alkylene group; and R12 represents a hydroxy gro up or an alkoxy group.