2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES

The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimi dines inhibitors which are inhibitors and therefore inhibit Protein Kinase C -alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in impr...

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Bibliographische Detailangaben
Hauptverfasser:	GOLEBIOWSKI, ADAM, DJUNG, JANE FAR-JINE, HUNTER, JACK A, SHRUM, GARY P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimi dines inhibitors which are inhibitors and therefore inhibit Protein Kinase C -alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improve d myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compo sitions comprising said 2-arylamino-4-(aminoalkylene)amino-pyrimidines and t o methods for controlling, abating, or otherwise slowing the progression of heart failure.