SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The invention relates to substituted aminopyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositi ons comprising said substituted aminopyrazolopyridines, to methods of prep...

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Bibliographische Detailangaben
Hauptverfasser: THIERAUCH, KARL-HEINZ, TER LAAK, ANTONIUS M, INCE, STUART, HARTUNG, INGO, BRIEM, HANS, KETTSCHAU, GEORG, SCHWEDE, WOLFGANG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to substituted aminopyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositi ons comprising said substituted aminopyrazolopyridines, to methods of prepar ing said substituted aminopyrazolopyridines as well as the use thereof for m anufacturing a pharmaceutical composition for the treatment of diseases of d ysregulated vascular growth or of diseases which are accompanied with dysreg ulated vascular growth, wherein the compounds effectively interfere with Tie 2 signalling.