PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of...

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Bibliographische Detailangaben
Hauptverfasser:	BREITENBACH, JOERG, KESSLER, THOMAS, DEGENHARDT, MATTHIAS, KRULL, HARALD, SCHMIDT, CHRISTOPH, ROSENBERG, JOERG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING BABY COMFORTERS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (figure 2). L'invention concerne un procédé de production d'une dispersion solide d'un principe actif actif. Ce procédé consiste à envoyer le principe actif et un agent de formation de matrice dans un extrudeur, puis à former un extrudat uniforme. L'extrudeur comprend au moins deux arbres rotatifs (2), chaque arbre (2) portant une pluralité d'éléments de traitement montés axialement les uns derrière les autres. Les éléments de traitement définisssent (i) une partie d'alimentation et de transfert (A), (ii) au moins une partie de mélange (B) et (iii) une partie d'évacuation (E). Le ou les éléments de traitement définissant la partie de mélange B comprenne(nt) un élément de mélange (11, 12, 13) dérivé d'un élément de type écrou (figure 2).