JOINING AND/OR SEALING TISSUES THROUGH PHOTO-ACTIVATED CROSS-LINKING OF MATRIX PROTEINS

A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivata...

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Bibliographische Detailangaben
Hauptverfasser:	BROWNLEE, ALAN GEORGE, ELVIN, CHRISTOPHER MALCOLM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE ADHESIVES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR DYES HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL PAINTS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES USE OF MATERIALS AS ADHESIVES
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Beschreibung
Zusammenfassung:	A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion. L'invention concerne une méthode de jonction et/ou d'assemblage de tissus lors d'une intervention chirurgicale ou d'un traitement médical. Les étapes de cette méthode consistent à : (1) appliquer une protéine matricielle, un complexe métal-ligand photoactivable et un accepteur d'électrons sur une portion de tissu, (2) irradier ladite portion de tissu afin de photoactiver le complexe métal-ligand photoactivable et d'amorcer ainsi une réaction de réticulation de la protéine matricielle afin de coller ladite portion de tissu ou de joindre ladite portion de tissu avec une portion de tissu adjacente.