THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS

The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, XIANGHONG, HAN, NIANHE, HUANG, XIN, WOHLHIETER, GEORGE ERIC, LIU, QINGYIAN, LI, AIWEN, LEE, MATTHEW R, RIDER, JAMES THOMAS, ALLEN, JOHN GORDON, FOTSCH, CHRISTOPHER H, YUAN, CHESTER CHENGUANG, ZENG, QINGPING, WEILER, KURT E, YAO, GUOMIN, VISWANADHAN, VELLARKAD NARAYANA, BOURBEAU, MATTHEW PAUL, DOMINGUEZ, CELIA, TASKER, ANDREW S, TADESSE, SEIFU, HONG, FANG-TSAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.