NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE

NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds of formula (I), (see formula I) wherein R1, (R2)n and R3 are defined herein, which are capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-relate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DOHERTY, ELIZABETH M, PARAS, NICK A, NIXEY, THOMAS, SMITH, ADRIAN LEONARD, KIM, JOSEPH L, RETZ, DANIEL MARTIN, CHEN, JIAN J, LIU, GANG, TASKER, ANDREW, DE MORIN, FRENEL F, HUANG, QI, ZHU, JIAWANG, PETKUS, JEFFREY, HITCHCOCK, STEPHEN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention comprises a new class of compounds of formula (I), (see formula I) wherein R1, (R2)n and R3 are defined herein, which are capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.