BIS-PLATINUM COMPLEXES WITH ANTITUMOR ACTIVITY

A compound of general formula (I): (see formula I) in which: R is (C3-C7)alkyl; n and m are each independently an integer of five or six; p is one or two; A is -W-(CH2)r-W-, wherein r is an integer from 2 to 4, W is a -NR1- or -N(R2)2+ 1/pQ-p group, in which R1 is hydrogen or tert-butoxycarbonyl, an...

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Bibliographische Detailangaben
Hauptverfasser:	GRUGNI, MARIO, NICOLI, PAOLA, BERNAREGGI, ALBERTO, PARDI, GIANLUCA, MARIOTTI, GIULIO, PAVESI, PAOLO, MENTA, ERNESTO, PEZZONI, GABRIELLA, DE MUNARI, SERGIO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A compound of general formula (I): (see formula I) in which: R is (C3-C7)alkyl; n and m are each independently an integer of five or six; p is one or two; A is -W-(CH2)r-W-, wherein r is an integer from 2 to 4, W is a -NR1- or -N(R2)2+ 1/pQ-p group, in which R1 is hydrogen or tert-butoxycarbonyl, and R2 is hydrogen; Q-p is an anion selected from the group consisting of chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, and perchlorate, R3COO- wherein R3 has the same meanings as R, independently from one another, and R4-O-SO3- wherein R4 is (C2-C14)alkyl with the proviso that, when Q-p is chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, or perchlorate, R is not (C3-C4)alkyl. The compounds of the present invention are useful in the preparation of medicaments for the treatment of tumours.