STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF

STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF

The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7--bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the A polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the...

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Bibliographische Detailangaben
Hauptverfasser: CONNELL, RICHARD D, FERRANTE, KAREN J, SILBERMAN, SANDRA L, MOYER, JAMES D, RAGGON, JEFFREY W, FOSTER, BARBARA A, KAJIJI, SHAMA M, NORRIS, TIMOTHY, MORIN, MICHAEL J
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
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Zusammenfassung:The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7--bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the A polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph A form of N-(3--ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.