AMINOPHENYLSULFONAMIDE DERIVATIVES AS HIV PROTEASE INHIBITOR

AMINOPHENYLSULFONAMIDE DERIVATIVES AS HIV PROTEASE INHIBITOR

The present invention concerns substituted aminophenylsulfonamide compounds and derivatives having the formula (see formula I) their use as protease inhibitors, in particular as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnost...

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Bibliographische Detailangaben
Hauptverfasser: BOONANTS, PAUL JOZEF GABRIEL MARIA, DE KOCK, HERMAN AUGUSTINUS, JONCKERS, TIM HUGO MARIA, LAST, STEFAAN JULIEN, SURLERAUX, DOMINIQUE LOUIS NESTOR GHISLAIN, WIGERINCK, PIET TOM BERT PAUL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention concerns substituted aminophenylsulfonamide compounds and derivatives having the formula (see formula I) their use as protease inhibitors, in particular as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present substituted aminophenylsulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.