METHOD OF INHIBITING FLT3 KINASE

A method of reducing or inhibiting kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 using a compound of the present invention (I), or a solvate, hydrate, tautomer or ph...

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Bibliographische Detailangaben
Hauptverfasser:	BALLENTINE, SHELLEY K, WILSON, KENNETH, WALL, MARK J, BAUMANN, CHRISTIAN ANDREW, ILLIG, CARL R, RUDOLPH, M. JONATHAN, TUMAN, ROBERT W, CHEN, JINGSHENG, MEEGALLA, SANETH, JOHNSON, DANA L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A method of reducing or inhibiting kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 using a compound of the present invention (I), or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders. L'invention porte sur une méthode de réduction ou d'inhibition de l'activité de kinase du récepteur FLT3 dans une cellule ou un patient, pour prévenir ou traiter chez un patient les troubles de prolifération cellulaire et/ou liés au FLT3, en utilisant le composé de l'invention (l) ou un de ses solvates, hydrate, tautomère ou sel pharmacocompatible. L'invention porte également sur des méthodes de traitement d'états tels que le cancer ou d'autres troubles de prolifération cellulaire.