BICYCLO[2.2.]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES

Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group -N(R12)-;(i) R1 is C1-C6-alk yl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, -Z-Y-R5 -Z- NR9R10; -Z-CO-NR9R10; -Z-NR9-CO-R5; or -Z-CO2H; and R3 is a lone pair,or C1- C6- aIkyl in which case the nitrogen atom to which it is attached is a quaternar y nitrogen and carries a positive charge; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group -R5, -Z-Y-R5, -Z-NR9R10, -Z-CO-NR9R10, -Z-NR9-CO-R 5 , or -Z-CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R1 and R2 togeth er with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group -Y-R5, -Z-Y-R5, -Z-NR9R10; -Z-CO- NR9R10; -Z-NR9-CO-R5; or -Z-CO2H and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitroge n and carries a positive charge; R4 is a group of formula (a), (b), (c) or (d) ; is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.