USE OF ANTI-NGF ANTIBODY FOR IMPROVING STIFFNESS IN OSTEOARTHRITIS

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies e.g. E3 anti-NGF antibody comprising the heavy chain CDRs of SEQ ID NOs: 3-5 and the light chain CDRs of SEQ ID NOs: 6-8), and polynucleotides encoding the same. The invention further concerns use of such antibodies a...

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Bibliographische Detailangaben
Hauptverfasser:	SHELTON, DAVID L, ROSENTHAL, ARNON, WALICKE, PATRICIA ANN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies e.g. E3 anti-NGF antibody comprising the heavy chain CDRs of SEQ ID NOs: 3-5 and the light chain CDRs of SEQ ID NOs: 6-8), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain. La présente invention concerne des anticorps anti-NGF tels que des anticorps antagonistes anti-NGF, et des polynucléotides les codant. L'invention concerne également l'utilisation de tels anticorps et/ou polynucléotides pour le traitement et/ou la prévention des douleurs, (postopératoires, polyarthrite rhumatoïde, arthrose).